Eleftheria Maratos-Flier, MD

Part I: General Information

Education

• 1972 B.A. New York University, New York, New York
• 1976 M.D. Mount Sinai School of Medicine, New York, New York

Postdoctoral training

• 1976-1977 Intern in Medicine, George Washington University Hospital, Washington, D.C.
• 1977-1978 Resident in Medicine, George Washington University Hospital
• 1978-1979 Resident in Medicine, Beth Israel Hospital, Boston, MA
• 1978-1979 Clinical Fellow of Medicine, Harvard Medical School
• 1979-1981 Research Fellow of Toxicology Harvard School of Public Health
• 1981-1982 Research Fellow in Medicine, Harvard Medical School and Brigham and Women's Hospital
• 1981-1982 Research Fellow Section of Cellular Joslin Diabetes Center and Molecular Physiology, Research Division

Licensure and Certification

• 1979 Massachusetts License Registration
• 1979 American Board of Internal Medicine

Academic Appointments

• 1982-1987 Instructor in Medicine, Harvard Medical School
• 1987-1999 Assistant Professor of Medicine Harvard Medical School
• 1999-present Associate Professor of Medicine Harvard Medical School

Hospital or Affiliated Institution Appointments

• 1982-1999 Associate Physician.Brigham and Women's Hospital, Boston, Massachusetts
• 1987-present Active Provisional Staff Beth Israel Deaconess Medical Center, Boston, Massachusetts
• 1999-present Courtesy Staff, Brigham and Women's Hospital

Other Professional Positions

• 1982-1983 Research Associate, Joslin Diabetes Center, Section of Cellular and Molecular Physiology, Boston, Massachusetts
• 1984-2000 Investigator, Joslin Diabetes Center, Section of Cellular and Molecular Physiology, Boston, Massachusetts
• 2000-present Head, Section on Obesity, Joslin Diabetes Center, Senior Investigator, Boston, Massachusetts
• 2001-present Affiliate Faculty, Program in Neuroscience, Harvard Medical School
• 2002-present Senior Research Advisor, Peabody Society, Harvard Medical School

Hospital and Health Care Organization Service Responsibilities

• 1982-1990 Diabetes Attending, Joslin Diabetes Center
• 1982-1996 Diabetes Attending, Brigham and Women's Hospital
• 1982-2000 Diabetes Outpatient Clinic, Brigham and Women's Hospital
• 2000-2004 Diabetes Outpatient Clinic, Joslin Diabetes Center
• 2004-present Staff Physician, Beth Israel Deaconess

Major Administrative Responsibilities

• 1984-1986 Co-Organizer Longwood Medical Area Diabetes Seminar Series
• 1991-1994 Co-Organizer Longwood Medical Area Diabetes Seminar Series
• 1994-2002 Director, Molecular Core, Joslin Diabetes Center
• 1999-2002 Organizer, Longwood Medical Area Diabetes Seminar Series
• 2002-2004 Director, Animal Physiology Core, Joslin Diabetes Center
• 2004-present Director, Animal Physiology Core, Division of Endocrinology, Beth Israel Deaconess Medical Center

Major Committee Assignments

• 1998-present Joslin Animal Care Committee (IACUC)
• 1999-2002 Endocrine Society - Annual Meeting Steering Committee>
• 2002-present Ad Hoc Reviewer, Special Study Section /NPSA/NIH

Professional Societies

• 1984-present American Diabetes Association, Member
• 1987-present The Peabody Society, Harvard Medical School, Member
• 1996-present The Endocrine Society, Member

Community Service Related to Professional Work

• 1983-present Volunteer science teaching in elementary and high school
• 1993-present Co-manager of an academic internet discussion list on healthcare reform, "Healthre"

Editorial Boards

• 1999-2003 Endocrinology
• 2002-present Obesity Research, Associate Editor

Awards and Honors

• 1972 Phi Beta Kappa
• 1980 Postdoctoral Fellowship, American Cancer Society
• 1981-1982 Mary K. Iacocca Research Fellowship, Joslin Diabetes Center
• 1998, 2002 Merck Senior Fellows Award to Maratos-Flier's Fellows
• 2003 Association of American Physicians (AAP)

PART II: Research, Teaching and Clinical Contributions

Report of Research

Major Research Interests
• Melanin Concentrating Hormone: Physiology and Mechanism of Action
• Hypothalamic peptides and appetite regulation
• Interaction of leptin with other regulators of eating behavior
• Obesity and glucose tolerance

Narrative Report
• Obesity is a significant risk factor for the development of type II diabetes. Although the prevalence of obesity is common, the causes of obesity are poorly understood. Energy balance is regulated by a complex interaction between the periphery and the central nervous system. My major interest is in the mechanisms by which melanin concentrating hormone (MCH) plays a role in energy homeostasis and in integrating signals from the environment. My laboratory initially discovered the orexigenic role of MCH using RT-PCR differential display. We found that mRNA for MCH is elevated in the hypothalamus of the leptin deficient ob/ob mouse, is regulated by fasting and that administration of MCH intracerebroventricularly into rodents led to a rapid and reproducible increase in feeding behavior.
  I have subsequently followed up on this finding by generating both a line of mice lacking MCH which are lean, and a line of mice overexpressing MCH which are susceptible to diet induced obesity. Findings with the lean MCH null mice have been of significant interest; in addition to being lean these mice have significant olfactory deficits as demonstrated by behavioral deficits in mating and in tasks involving finding food . This leads me to believe that MCH is important in integrating signals from the environment, an area my laboratory is actively pursuing.
  Once the MCH-receptor was identified we mapped expression in the brain of mice and found that it is heavily expressed in regions of the brain involved in olfaction including the olfactory tubercle and piriform cortex suggesting that MCH may be important in integrating olfactory information. Part of the current work in my laboratory is to develop biochemical, behavioral and anatomic correlates for MCH signaling in olfactory areas of the brain.
  In addition we have used the MCH null model to further examine the role of MCH in mediating obesity in various obese models. Thus far we have found that absence of MCH attenuates obesity in ob/ob mice as well as in Ay mice which are obese due to abnormal melanocortin signaling; MCH-null mice appear to be resistant to diet induced obesity.
  An additional area of interest is determining the role of neuropeptides, including MCH and other orexigenic factors such as NPY and AGRP as well as neuropeptides that diminish appetite such as MSH and CART, in the development of diet induced obesity in mice.

Teaching
• My current teaching responsibilities involve the ongoing supervision of four post-doctoral research fellows in my laboratory. I am supervising the senior thesis of a senior at Harvard college. I mentor and act as a senior advisor to two junior level investigators. I also participate as an invited speaker in the CBC course and in the IHP course at Harvard Medical School. I teach in the Endocrinology course organized by Dr. Monty Krieger at MIT.
  I also serve as a tutor in the second year HMS course "Nutrition and Preventitive Medicine".

Clinical Contributions
• I see outpatients with diabetes one morning every other week as a consultant. This clinical activity took place at Joslin Diabetes Center and is being relocated to Beth Israel Deaconess Medical Center. Approximately 90% of my patients involve long term follow up. The one morning clinic generates an addition two to four hours of follow up time in the form of patient phone calls and communication with referring physicians. Diabetes particularly requires particularly intensive phone follow up for the purpose of blood sugar monitoring.

Research Funding Information (entirely for bench research)

• 1983-1984 Juvenile Diabetes, PI, "Viral Interactions with Foundation 82R609 Beta Cells"
• 1984-1989 NIH Award 5K08AM1252, Clinical Investigator PI, "Viral Pathogenesis in Endocrine Cells"
• 1984-1986 American Diabetes Association, "Cellular Processing of Reovirus and Infection of Islet Cells"
• 1989-1992 American Heart Association, PI, "Viral Receptors on Endocrine Cells"
• 1990-1995 NIH R01 A128971-05, PI, "Molecular Characterization of the Reovirus Receptor"
• 1994-1999 Markey Charitable Trust, PI, "DNA Sequencing & Oligonucleotide Synthesis Core"
• 1995-1996 Boston Obesity Research Center NIH 5P30DK46200-04, PI, "Identification of Novel Hypothalamic Genes that are Differentially Regulated"
• 1996-1997 American Diabetes Association, PI, "Melanin Concentrating Hormone:A Novel Orexigenic Neuropeptide"
• 1996-1998 Eli Lilly and Company, PI, Study directed to Obesity, Energy Homeostasis and Metabolic Control
• 1996-1997 NIH 5P30DK36836-11, PI, "MCH: A Novel Regulator of Feeding Behavior"
• 1998-2003 NIH 1R01DK53978-0 5, PI, "Anatomic and Physiologic Characterization of MCH Action"
• 1999-present NIH 1R01DK56113-02, PI, "Gene Targeting Approaches to MCH and Energy Balance"
• 2000-present NIH 1P01DK56116-02, PI, J.S. Flier PI on Program Project, Program Project Grant with BIDMC

Report on Current Research Activities:

• Anatomic and physiologic characterization of melanin concentrating hormone, PI
• Characterization of animals with ablation of the gene for melanin concentrating hormone, PI
• Characterization of MCH receptor and pathways of MCH signal transduction, PI
• Behavioral effects of MCH and MCH ablation, PI

Report on Teaching

Local Contributions

• Medical School Courses
  • 1982-1996 Teaching of residents and fellows while Attending Physician at Brigham and Women's Hospital, Boston, Massachusetts
  • 1982-2004 Supervised research training of 1-2 M.D. Postdoctoral Fellows, medical and college students and Research Assistants at the Joslin Diabetes Center, Boston, Massachusetts
  • 2004-present Supervised research training of 3-4 MD or PhD postdoctoral fellows, medical students and undergraduates in the Endocrine Division of Beth Israel Deaconess Medical Center
  • 1984-1988 First year medical tutor at Harvard Medical School, Boston, Massachusetts.
  • 1988-1992 Tutor in Patient/Doctor I, Harvard Medical School - This course meets weekly throughout the academic year. In addition to a two hour tutorial approximately two additional weeks of time outside the classroom for observation of students, with patients, discussions and feedback were required.
  • 1991-1994 Advisor, Peabody Society in Pilot Advisory Program, Harvard Medical School
  • 1995-present Participated as lecturer and tutor in CBC, 5 hours each time
• Advisory and Supervisory Responsibilities
  • 1982-1996 While an attending physician at the Brigham I met with fellows and residents three times per week while on service (two months of the year.) The sessions were devoted to presentation of patients and discussion and teaching. (They were not used for provision of clinical services.)
  • 1994- Supervise research for two research fellow approximately 350 hrs/yr.
• Advisees and Trainees:
  • Eric Verdin (postdoctoral fellow), Professor of Medicine, UCSF
  • Louise Montgomery (postdoctoral fellow), Associate Professor of Biology, Chairman Department of Biology, Marymount University, Arlington, VA
  • Ali El-Ghorr (postdoctoral fellow), Faculty Division of Biomedicine and Clinical Laboratory Sciences, University of Edinburgh
  • David Ludwig (postdoctoral fellow), Assistant Professor, Harvard Medical School, Children's Hospital, Boston
  • Daqing Qu, (postdoctoral fellow), Research Scientist, Millipore Corporation
  • Nicholas Tritos, (postdoctoral fellow), Endocrinology Private Practice, Boston
  • Richard Bradley (postdoctoral fellow), Instructor in Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston
  • Jason Mastaitis (pre-doc), Graduate student, Department of Neurobiology, Mount Sinai School of Medicine, New York, New York
  • Daniel Trombly (pre-doc), Graduate student, Department of Neuroscience, Northwestern University, Chicago, Illinois
  • Jason Karamachandran (senior thesis) Medical Student, Stanford University, San Francisco, California
  • Neha Jadeja, (senior thesis), Medical Student, Harvard Medical School, Boston
  • Gabriella Segal-Lieberman, Assistant Professor of Medicine, Sheba Medical Center, Institute of Endocrinology, Ramat-Gan, Israel
  • Efi Kokkotou, Instructor in Medicine, Harvard Medical School, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston

Regional, National or International Contributions Symposium Lecturer

• Aug. 1996 Aspen Lipid Conference
• Feb. 1997 Maui Meeting on Diabetes and Obesity
• June 1997 Endocrine Society, 79th Annual Meeting, Symposium Speaker
• July 1997 International Diabetes Foundation, Helsinki Meeting
• Sep. 1997 National Institute of Health, NIDDK, "The Brain and the Adipocyte"
• Mar. 1998 Pennington Biomedical Research Center, "Nutrition, Genetics and Obesity"
• June 1998 American Diabetes Association, 58th Annual Meeting, Symposium Speaker "Neuroendocrine Regulation of Energy Balance and Satiety"
• Aug. 1998 Adipo- Science Meeting, Osaka, Japan
• Oct. 1998 Banbury Conference/Cold Spring Harbor, The Molecular Physiology of Weight Regulation and Obesity
• Jun. 1999 Endocrine Society, 81st Meeting, Symposium Speaker
• Feb. 2000 Keystone Symposium, Invited Speaker
• Oct. 2000 Inaugural Obesity Research Center Symposium, Boston University, Invited Speaker
• Feb 2001 Keystone Symposium, Invited Speaker
• Jan 2002 Keystone Symposium, Molecular Control of Adipogenesis and Obesity, Invited Speaker
• July 2002 Gordon Research Conference, Mechanism of Hormone Action, Invited Speaker
• Feb 2003 AAAS Symposium Speaker
• May 2003 Pat Usher Memorial Lecture, Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA
• March 2004 Days of Molecular Medicine, Cambridge, England, Invited Symposium Speaker
• June 2004 8th Neuroendocrine Workship, Invited Speaker
• June 2004 Endocrine Society 86th Annual Meeting, Symposium Speaker
• January 2005 Keystone Symposium, Invited Speaker

PART III: Bibliography

Original Reports

1. Halpern AM, Maratos E. Excimer formation in saturated amines. J Am Chem Soc 1972; 94:8273-8275.
2. Maratos E, Taub RN, Bramis J. Amelioration of streptozotocin-induced diabetes in mice by the implantation of pancreatic islets in diffusion chambers. Mt Sinai J Med NY 1976; 43:415-422.
3. Flier JS, Maratos-Flier E, McIsaac D, Pallotta J. Endogenous digitalis-like activity circulates in the plasma of the toad, bufo marinus. Nature 1979; 279:342-344.
4. Maratos-Flier E, Spriggs DR, Fields BN, Kahn CR. Specific plasma membrane receptor for reovirus on rat pituitary cells in culture. J Clin Invest 1983; 72:617.
5. Maratos-Flier E, Goodman MJ, Fields BN, Kahn CR. Differential effects of viral infection on islet and pituitary cells in culture. Endocrinology 1985; 116:2430-2437.
6. Maratos-Flier E, Goodman MJ, Murray AH, Kahn CR. Ammonium inhibits processing and cytotoxity of a non-enveloped virus. J Clin Invest 1986; 78:1003-1007.
7. Verdin EM, Maratos-Flier E, Carpentier JL, Kahn CR. Persistent infection with a non-transforming virus leads to altered expression of growth factor receptors and responses. J Cell Physiol 1986; 128:457-465.
8. Verdin EM, Maratos-Flier E, Kahn CR, Sodoyez JC, Sodoyez-Goffaux F, De Vos CJ, Lynn SP, Fields BN. Visualization of viral clearance in the living animal. Science 1987; 236:439-442
9. Maratos-Flier E, Kao CY-Y, Verdin EM, King GL. Receptor mediated vectorial transcytosis of epidermal growth factor by MDCK cells. J Cell Biol 1987; 105:1595-1601.
10. Verdin EM, Lynn, SP, Fields BN, Maratos-Flier, E. Uptake of reovirus serotype I by the lungs from the bloodstream is mediated by the viral hemaglutinin. J Virol 1988; 62:545-551.
11. Verdin EM, King GL, Maratos-Flier EM. Characterization of a common high-affinity receptor for reovirus serotypes 1 and 3 on endothelial cells. J Virol 1989; 63:1318-1323.
12. Montgomery LB, Kao C-Y-Y, Verdin E, Cahill C, Maratos-Flier E. Infection of a polarized epithelial cell line with wild type reovirus leads to viral persistence and altered cellular function. J Gen Virol 1991; 72:2939-2946.
13. El-Ghorr AA, Gordon D, George K, and Maratos-Flier E. Regulation of expression of the reovirus on differentiated HL60 cells. J Gen Virol 1992; 73:1961-1968.
14. Qu D, Ludwig DS, Gammeltoft S, Piper M, Pelleymounter MA, Cullen MJ, Mathes WF, Przypek J, Kanarek R, Maratos-Flier E. A role for melanin-concentrating hormone in the central regulation of feeding behavior. Nature 1996; 380:243-247.
15. Mantzoros CS, Qu D, Frederich RC, Susulic VS, Lowell BB, Maratos-Flier E, Flier JS. Activation of ?-3 adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice. Diabetes 1996;45:909-914.
16. Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, Flier JS. Role of leptin in the neuroendocrine response to fasting. Nature 1996; 382:250-252.
17. Elmquist JK, Ahima RS, Maratos-Flier E, Flier JS, Saper CB. Leptin activates neurons in ventrobasal hypothalamus and brainstem. Endocrinology 1997; 138(2): 839-842
18. Mantzoros CS, Frederich RC, Qu D, Lowell BB, Maratos-Flier E, Flier JS. Severe leptin resistance in brown fat deficient UCP-DTA mice despite suppression of hypothalamic NPY. Diabetes 1998; 47:230-238.
19. Ludwig DS, Mountjoy KG, Tatro JB, Gillette JA, Frederich RC, Flier JS, Maratos-Flier E. Melanin-concentrating hormone: a functional melanocortin antagonist in the hypothalamus. Am J Physiol 1998; 274:E627-33
20. Vicent D, Piper M, Gammeltoft S, Maratos-Flier E, Kahn CR. Alterations in skeletal muscle gene expression of ob/ob mice by mRNA Differential Display. Diabetes, in press.
21. Tritos N, Vicent D, Gillete J, Ludwig DS, Flier E, Maratos-Flier E, Functional interactions between melanin concentrating hormone, neuropeptide Y and Anorectic neuropeptides in the Rat Hypothalamus. Diabetes, 1998;47:1687-1692.
22. Tritos N, Elmquist JK, Mastaitis JW, Maratos-Flier E. Altered expression of multiple orexigenic peptide mRNAs in the hypothalamus of obese hyperleptinemic UCP-DTA mice. Endocrinology 1998;139:4634-4641.
23. Elmquist JK, Maratos-flier E. Saper CB, Flier JS. Unraveling the central nervous system pathways underlying responses to leptin. Nat Neuroscience 1998; 6:445-450.
24. Shimada M, Tritos N, Lowell BB, Flier JS, Maratos-Flier E. Absence of melanin concentrating hormone produces hypophagia and a lean phenotype. Nature 1998 396:670-674.
25. Elias CF, Saper CB, Maratos-Flier E, Tritos N, Lee C, Kelly J, Ollmann MM, Barsh GS, Sakurai T, Yanagisawa M, Elmquist JK. Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic are. Journal of Comparative Neurology 1998 4:442-459.
26. Vicent D, Maratos Flier E, Kahn CR. The branch point enzyme of the mevalonate pathway for protein prenylation is overexpressed in the ob/ob mouse and induced by adipogenesis. Mol Cell Biol. 2000 6:2158 66.
27. Bradley R, Kokkotou E, Maratos Flier E, Cheatham B, Melanin-concentrating hormone regulates leptin synthesis and secretion in rat adipocytes. Diabetes 2000 49:1073-1077.
28. Kokkotou E, Mastaitis JW, Qu D, Hoersch D, Bonter K, Slieker L, Tritos NA, Maratos Flier E. Characterization of [Phe13, Tyr19]-MCH analog binding activity to the MCH receptor. Neuropeptides 2000 34:240-247.
29. Kokkotou EG, Tritos NA, Mastaitis JW, Slieker L, Maratos-Flier E. Melanin Concentrating Hormone Receptor is a target of leptin action in the mouse brain. Endocrinology 2001 142:680-686.
30. Ludwig DS, Tritos NA, Mastaitis JW, Kulkarni R, Kokkotou E, Lowell B, Flier JS, Maratos-Flier E. Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. J. Clin. Invest. 2001 107:379-386.
31. Tritos NA, Mastaitis JW, Maratos-Flier E. Characterization of melanin concentrating hormone and pre-pro-orexin expression in the murine hypothalamus. Brain Research, Brain Res. 2001 895(1-2):160-6.
32. Bradley RL, Mansfield JP, Maratos-Flier E, Cheatham B. Melanin-concentrating hormone activates signaling pathways in 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab 2002 Sep;283(3):E584-92
33. Tritos NA, Mastaitis J, Kokkotou, Puigserver P, Spiegelman B, Maratos-Flier E. Characterization of the peroxisome proliferator activated receptor coactivator 1 alpha (PGC-1?) expression in the murine brain. Brain Research 2003 961:255-60.
34. Bates SH, Stearns WH, Dundon TA, Schubert M, Tso AWK, Wang Y, Banks AS, Lavery HJ, Haq AK, Maratos-Flier E, Neel BG, Schwartz MW, Myers MG. Stat 3 signaling is required for leptin regulation of energy balance but not reproduction, Nature 2003 421:856-9
35. Segal-Lieberman G, Trombly DJ, Juthani V, Wang X, Maratos-Flier E. NPY ablation in C57BL/6 mice leads to mild obesity and to an impaired refeeding response to fasting, e-published ahead of print, Am J Physiol Endocrinol Metab. 2003; 284(6):E1131-9
36. Pissios P, Trombly DJ, Tzameli I, Maratos-Flier E. Melanin-concentrating hormone receptor 1 activate ERK and synergizes with Gs coupled pathways. Endocrinology. 2003; 144(8):3514-23.
37. Segal-Lieberman G, Bradley RL, Kokkotou E, Carlson M, Trobmly DJ, Wang X, Bates S, Myers MG Jr., Flier JS, Maratos-Flier E. Melanin-concentrating hormone is a critical mediator of the leptin deficient phenotype. Proc Natl Acad Sci U S A. 2003;100(17):10085-90.
38. Tritos NA, Kokkinos A, Lampadariou E, Alexiou E, Katsilambros N, Maratos-Flier E. Cerebrospinal fluid ghrelin is negatively associated with body mass index. J Clin Endocrinol Metab. 2003;88(6):2943-6.
39. Tritos NA, Mun E, Bertkau A, Grayson R, Maratos-Flier E, Goldfine A. Serum ghrelin levels in response to glucose load in obese subjects post-gastric bypass surgery. Obes Res. 2003;11(8):919-24.
40. Bluher S, Ziotopoulou M, Bullen JW Jr, Moschos SJ, Ungsunan L, Kokkotou E, Maratos-Flier E, Mantzoros CS. Responsiveness to peripherally administered melanocortins in lean and obese mice. Diabetes. 2004 Jan;53(1):82-90.
41. Bluher S, Moschos S, Bullen J, Kokkotou E, Maratos-Flier E, Wiegand SJ, Sleeman MW, Mantzoros CS. CNTF Ax15 alters energy homeostasis, decreases body weight and improves metabolic control in diet-induced obese and UCP1-DTA mice. Diabetes. 2004 In press.
42. Tritos NA, Segal-Lieberman G, Vezerides PS, Maratos-Flier E. Estradiol-induced anorexia is independent of leptin and melanin concentrating hormone. Obesity Research. 2004 12:716-724.
43. Gibson WT, Pissios P, Trombly DJ, Luan J, Keogh J, Wareham NJ, Maratos-Flier E, O'Rahilly S, Farooqi IS. Melanin-concentrating hormone receptor mutations and human obesity: functional analysis. Obesity Research. 2004 12:743-749.
44. Bullen JW Jr, Ziotopoulou M, Ungsunan L, Misra J, Alevizos I, Kokkotou E, Maratos-Flier E, Stephanopoulos G, Mantzoros CS. Short-term resistance to diet-induced obesity in A/J mice is not associated with regulation of hypothalamic neuropeptides. Am J Physiol Endocrinol Metab. 2004 287:E662-70
45. Bluher S, Moschos S, Bullen J Jr, Kokkotou E, Maratos-Flier E, Wiegand SJ, Sleemann MW, Mantzoros CS. Ciliary neurotrophic factorAx15 alters energy homeostasis, decreases body weight, and improves metabolic control in diet-induced obese and UCP1-DTA mice. Diabetes. 2004 53:2787-96.
46. Bates SH, Dundon TA, Seifert M, Carlson M, Maratos-Flier E, Myers MG Jr. LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin. Diabetes. 2004 Dec 53:3067-73.
47. Bradley JR, Mansfield JPR. Maratos-Flier E. Neuropeptides Including Neuropeptide Y and Melanocortins Mediate Lipolysis in Murine Adipocytes. Obesity Research 2005, In Press
48. Kokkotou E, Jeon JY, Wang X, Marino FE, Carlson M, Trombly DJ, Maratos-Flier E. Mice with MCH ablation resist diet induced obesity through strain specific mechanisms. Am J Physiology. 2005, In Press
49. Georgescu D, Sears RM, Hommel JD, Barrot M, Bolanos CA, Marsh DJ, Bednarek MA, Bibb JA, Maratos-Flier E, Nestler EJ, DiLeone RJ. The Hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance. J Neuroscience. 2005 In Press.

Reviews, Chapters and Editorials

1. Flier JS, Maratos Flier E. Health care reform: a free market perspective. Diabetes Reviews 1994;2(4):359 367.
2. Maratos Flier E. Oral agents for the treatment of type II diabetes mellitus. In: Becker KL Principles and Practice of Endocrinology and Metabolism, Second Edition. Philadelphia: J.B. Lippincott Company, 1995;1235 1238.
3. Maratos-Flier E, Goldstein BJ, Kahn CR. The insulin receptor and post receptor mechanisms. In: Pickup JC, Williams G, eds. Textbook of Diabetes, Second Edition. Oxford: Blackwell Science, Inc. 1997: 10.1-10.22.
4. Maratos-Flier E, Qu D, Gammeltoft S. Analysis of gene expression in hypothalamus in obese and normal mice using differential display. In: Pardee AB, Liang P, eds. Differential Display: Methods in molecular biology. Humana Press: 297-304.
5. Maratos-Flier E. Retroviruses and Endocrine Glands. In: Tyler K, Oldstone MAB, eds. Current Topics in Microbiology and Immunology. Volume 233/I and II. 1998
6. Flier, J.S. and Maratos-Flier E. Obesity and the Hypothalmus. Novel Peptides for New Pathways. Cell: 1998; 437-440.
7. Tritos NA, Maratos-Flier E. Two important systems in energy homeostasis: melanocortins and melanin-concentrating hormone. Neuropeptides: 1999 33:339-349
8. Flier JS, Maratos-Flier E. Energy Homeostasis and Body Weight. Curr Biol: 2000 23: R215-7.
9. Mobbs CV, Bray GA, Atkisnon RL, Bartke A, Finch CE, Maratos-Flier E, Crawley JN, Nelson JF. Neuroendocrine and pharmacological manipulations to assess how caloric restriction increases life span. J of Gerontology Series A - Biol. Sci. and Med. Sci. 2001 56:34-44
10. Maratos-Flier E and Flier JS. The stomach speaks - ghrelin and weight regulation. N Engl J Med. 2002 May 23;346(21):1662-3.
11. Pissios P and Maratos-Flier E. Melanin concentrating hormone: from fish skin to skinny mammals. Trends in Endocrinology and Metabolism. Trends Endocrinol Metab. 2003 Jul;14(5):243-8.
12. Maratos-Flier E and Flier JS. Obesity. Joslin's Diabetes Mellitus, 5th Edition. In Press
13. Bachman E and Maratos-Flier E. Appetite regulation and thermogenesis. In Press, Endocrinology, DeGroot, L. Editor.

ABSTRACTS

1. Flier JS, Maratos-Flier E, Kahn CR. Autoantibodies to the insulin receptor that block insulin binding fail to inhibit insulin degradation. Diabetes 1979; 26:354. 33(2):612A.
2. Verdin EM, Maratos-Flier E, Powers SL, Carpentier JL, Kahn CR. Altered growth factor receptors and action in cells after persistent viral infection. 67th Annual Meeting of the Endocrine Society; Baltimore, Maryland; 1985.
3. Maratos-Flier E, Verdin EM, Solomon RI, King GL. Characterization of the reovirus receptor and patterns of infection in endothelial cells. Clinical Research 1988; 36(3): 463A.
4. Maratos-Flier E, Yang-Kao CY, King GL. Phorbol esters have opposite effects on EGF binding and transcytosis in MDCK cells. The Endocrine Society 70th Annual Meeting, New Orleans, Louisiana, June 8-11, 1988.
5. Montgomery LB, George KL, Lobb R and Maratos-Flier E. Reovirus infection specifically alters expression of human endothelial cell surface antigens. Clinical Research 1990; 38(2):306A.
6. Montgomery LB, Maratos-Flier E. Characteristics of a persistent reovirus infection with wild type virus in a polarized epithelial cell line. American Society for Virology, 9th Annual Meeting, Salt Lake City, UT, July 8-12, 1990.
7. Montgomery LB, Gordon D, George K, Maratos-Flier E. Coxsackie infection of insulinoma cells leads to viral latency and altered insulin and class I MHR expression. Diabetes 1991: 360 (Supp. 1): 599A.
8. Gordon D, Montgomery LB, Sun Z, Maratos-Flier E. Coxsackie B4 persistence is associated with altered cellular function in an insulinoma cell line. American Society for Virology, 10th Annual Meeting, Fort Collins, CO, July 7-11, 1992.
9. El-Ghorr A, Gordon D, Maratos-Flier E. Characterization of some cell surface proteins that bind to reovirus. American Society for Virology, 11th Annual Meeting, Ithaca, NY, July 11-15, 1991.
10. Qu D, Mastaitis J, Tritos NA, Maratos-Flier E, MCH action is mediated through stimulation of a PI 3-kinase pathway. 80th Annual Meeting of the Endocrine Society. 1998.
11. Ozcan U, Pissios P, Kokkotou E, Maratos-Flier E, Kulkarni RN. Melanin concentrating hormone (MCH) stimulate insulin release via MCH receptors expressed in islets. Diabetes 51:106S Suppl.2 Jun 2002