The Barbara Kahn Lab: Lab Research
Our Major Research Interests
- Molecular mechanisms of insulin resistance.
- Molecular pathogenesis of type 2 diabetes.
- Pathogenesis of obesity.
- Insulin action, glucose transport, leptin action, metabolism.
- The adipocyte as an endocrine organ.
Recent Work
- Discovered new signaling pathway involved in leptin action - AMP activated protein kinase.
- Discovered importance of the Glut4 glucose transporter in adipocytes in whole body insulin action.
- Investigating the role of protein tyrosine phosphatase 1B and other phosphatases in insulin action and body weight regulation.
- Discovered that PTP1B regulates leptin signaling by dephosphorylating Jak 2.
Key Collaborators
More information coming soon.
